Micro Versus Nano in CBD Technology | Curatio
by Dionne Dyches
As healthcare practitioners continue to seek faster, more effective ways to provide pain relief, CBD is an encouraging approach. If success is measured by longer-lasting, quick-acting effects, absorption is the key to these promising results. CBD nanotechnology is outpacing traditional methods, creating an environment of increased certainty about absorption and bioavailability that has been lacking potassium sorbate isolates.
What Is CBD Nanoemulsion?
Cannabidiol (CBD) nanotechnology is a highly scientific process that breaks up cannabinoids and creates tiny particles of CBD (one billionth of a meter long). The resulting nanoparticles work their way through the bloodstream easier and more efficiently than regular-sized particles. These tiny particles open up a world of possibilities when it comes to food, drugs and products.
Micro vs. Nano — What’s the Difference?
Nanoemulsions (nano) and microemulsions (micro) are at the forefront of CBD technology. Nanos and micros are both transparent, have small particle size and low viscosity. However, they are not the same in the context of CBD — it’s critical to conduct thorough research on products because language used in a product’s marketing may be misleading. For instance, some companies may claim to offer CBD products that are “nano” when, in reality, they are “micro.” Curatio offers products that are true nanoemulsions, with particles that are 40 nanometers in length. Compared to products that are microemulsions, this difference can have a large impact on bioavailability and absorption.
The Science Behind CBD Nanotechnology
The body naturally produces its own nanoemulsions but to achieve greater absorption, that process must be mimicked by the carrier. Micelles, with their nano size, enable molecules that are insoluble in water, like lipids, to be absorbed. Although liposomes are commonly used emulsions, they do not imitate the body’s processes and are not readily absorbed. CBD is lipophilic so its natural tendency is to dissolve in oil or fats.
This is where miniaturizing, creating micro particles, makes the dramatic difference. With Curatio products, the particle size is 80,000 times smaller than a hair follicle. By reducing the particles to micron size, the manner in which they get absorbed also changes and increases the absorption rate by several fold.
Nanotechnology increases the rate of absorption even more, resulting in particles that are one billionth of a meter. Curatio particle size averages 32 nanometers with some as small 10 nanometers. When you consider that a strand of DNA is as small as 10 nanometers, the effect of nanotechnology for topical applications is even more significant making absorption become even more inevitable.
Challenges With Absorption and Bioavailability
Because water makes up most of the human body, hydrophilic substances offer the best absorption and bioavailability. Regardless of the carrier used to deliver the product, such as liposomes, the average absorption rate and best bioavailability ranges from 6 to 8%. (If, for example, the dose is 100 mg, only approximately 6 to 8 mg is being delivered to the bloodstream.) This is the challenge; to ensure that the most amount of product enters and remains in the bloodstream for as long as is possible.
Topical and Oral Bioavailability
Micelles are the key is greater absorption and bioavailability. The micelles emulsion Curatio develops imitates the micelles emulsions the body naturally creates. These very small oil droplets are miniaturized, then surrounded with minuscule water particles that suspend the oil. The body interprets the CBD to be water and thus, it is quickly dissolved.
Nanoemulsion for Rapid Onset and Better Bioavailability
Curatio products reach at least 70% absorption — up to ten times the absorption that occurs with traditional methods. Nanoemulsion more easily permeates the endodermis and creates larger surface areas for absorption. For the end user, this can mean the ability to feel the effects of the product in as little as 5 minutes versus a few hours. The result? Rapid onset and significantly longer duration of action, a half life that lasts longer than 12 hours.
Dionne Dyches, MS, is a communications professional and writer and specializing in the healthcare, hospital, and pharmaceuticals industry. Her niche includes internal communications, crisis communications, corporate communications, market research, management, and business development.